Science News Fibroblasts could provide new target for treatment of rheumatoid arthritis Date: University of Birmingham Summary: A new study reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for research into treatment of the disease. Synovial Fibroblasts (SFs) are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint. Synovial Fibroblasts (SFs) are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint. A team of researchers from the University of Birmingham’s Institute of Inflammation and Ageing identified two distinct types of SF within the synovial membrane. The team showed that these cell types, defined by the presence of specific cell surface markers (PDPN and CD248), aggregate in different layers of the synovium, and just one (the PDPN type) is responsible for cartilage damage in RA patients. During the study, SF cells from RA patients were grown in vitro within an artificial synovium, then ‘activated’ using stress-inducing proteins called cytokines. The artificial synovium containing the SFs was then inserted into a mouse (whose own immune system had been ‘switched off’), along with human cartilage to simulate a joint, to see how the SF cells would develop in vivo. Following implantation, tests showed that the ‘lining’ layer of the artificial synovium (i.e. the part closest to the cartilage) contained invasive PDPN type SFs, while the part that was further away from the cartilage contained the non-invasive CD248 type.
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22, 2016. (AP Photo/Armando Franca) More MADRID (AP) — Gareth Bale will need surgery on his right ankle and is expected to be sidelined for at least two months. Real Madrid says Bale will undergo the procedure on Tuesday in London. Bale limped off the field after getting hurt in the second half of Madrid’s 2-1 win over Sporting Lisbon in the Champions League on Tuesday. Madrid did not give a timetable for Bale’s recovery, but players who undergo similar procedures are usually out between two and three months. Bale is certain to miss the match against Barcelona on Dec. 3 at the Camp Nou, as well as FIFA’s Club World Cup later in the month. Reblog
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For instance, natives of Ireland, Scandinavia and Germany are at higher risk of getting sarcoidosis. In such cases, the immune system mistakenly attacks the body’s tissues and muscle. Certain viral and bacterial infections such as mumps, mycoplasma pneumonia and coxsackie B can also contribute to acute pancreatitis. Foods that can worsen inflammation are listed below, especially foods high in hydrogenated oils, sugars, and fats. find out this hereHydrogenated oils and their products Milk products high in fat content Make sure you include the above foods in your daily diet, also drink plenty of water. Alcohol: Excess alcohol consumption is one of the contributory factors that can cause inflammation. After you pour the boiling water on it, let it sit for about five to seven minutes. Kidney Cancer: As the kidney capsule enlarges slowly due to tumour, a slow dull pain is experienced by the person. bunionRelaxed ligaments in the sacroiliac joint, combined with additional weight and altered walking patterns places excessive stress on the joints. One can massage the pain area in circular movements with lukewarm clove oil.