When they cut wheat from their diets for 6 months, their immune system functioning went back to normal, and symptoms improved. The difference in the reaction may help explain why these people report symptoms like headaches in addition to GI symptoms. “The take-home message of our study’s findings is that there are objective biological changes in a significant number of individuals who report sensitivity to wheat without having celiac disease,” says study leader Armin Alaedini, PhD, an assistant professor of medicine at Columbia University Medical Center. For some, proteins found in wheat, called ATIs (amylase-trypsin inhibitors), may be triggering the symptoms. These proteins, which make up about 4% of wheat, act as the grain’s natural pesticide, warding off meal bugs and other invaders. They can also cause GI trouble. “ATIs are very important food components that can worsen chronic disease,” says Detlef Schuppan, MD, PhD, a professor of medicine at Harvard Medical School and a researcher at University Medical Center of the Johannes Gutenberg University in Mainz, Germany. His research on animals showed that the proteins can trigger powerful immune reactions in the gut, explaining some of the symptoms of non-celiac gluten sensitivity , he says. It may also help explain other inflammation -related conditions, such as rheumatoid arthritis , MS , and asthma , Schuppan says. top articleCarbohydrates in wheat that cause intestinal gas have also been implicated. However, some researchers now believe they cause, at most, a mild wheat intolerance.
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